Saria A, Lundberg J M
Naunyn Schmiedebergs Arch Pharmacol. 1983 Aug;323(4):341-2. doi: 10.1007/BF00512473.
Exposure of rat paws to noxious heat (hot water, 48 degrees C) led to an increase in vascular permeability to macromolecules as indicated by extravasation of Evans blue dye. After pretreatment of neonatal rats with 50 mg X kg-1 capsaicin s.c., which is known to cause degeneration of unmyelinated afferent neurones, this protein leakage was reduced by 74% (P less than 0.01). It is concluded that the oedema induced by noxious heat is partially caused by excitation of peripheral endings of capsaicin-sensitive primary afferent neurones.
将大鼠爪子暴露于有害热环境（48摄氏度热水）会导致大分子的血管通透性增加，伊文思蓝染料外渗表明了这一点。在用50mg/kg辣椒素皮下预处理新生大鼠后（已知辣椒素会导致无髓传入神经元变性），这种蛋白质渗漏减少了74%（P<0.01）。得出的结论是，有害热诱导的水肿部分是由辣椒素敏感的初级传入神经元外周末梢的兴奋引起的。
