Neill W A, Ritzmann L W, Selden R
Am Heart J. 1977 Oct;94(4):439-44. doi: 10.1016/s0002-8703(77)80037-9.
Clinical, coronary angiographic, and myocardial metabolic data were analyzed to test alternative hypotheses for the pathophysiologic basis of acute coronary insufficiency. The initial incidence of coronary collaterals was not low in relation to coexisting coronary obstructive disease; the early subsequent coronary occlusion rate was high; and in asymptomatic intervals during the acute illness, myocardial hypoxia was infrequent and coronary reserve substantial. These observations support the hypothesis that the acute coronary insufficiency syndrome is caused by reversible coronary ischemic episodes rather than by a new permanent atherosclerotic lesion.
对临床、冠状动脉造影和心肌代谢数据进行了分析，以检验关于急性冠状动脉供血不足病理生理基础的替代假说。相对于并存的冠状动脉阻塞性疾病，冠状动脉侧支的初始发生率并不低；随后早期冠状动脉闭塞率很高；并且在急性疾病的无症状间期，心肌缺氧很少见且冠状动脉储备充足。这些观察结果支持以下假说：急性冠状动脉供血不足综合征是由可逆性冠状动脉缺血发作引起的，而非由新的永久性动脉粥样硬化病变所致。
