海马体损伤会导致近交系小鼠在莫里斯水迷宫和条件性恐惧任务中出现学习缺陷。

Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task.

作者信息

Logue S F, Paylor R, Wehner J M

机构信息

Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA.

出版信息

Behav Neurosci. 1997 Feb;111(1):104-13. doi: 10.1037//0735-7044.111.1.104.

DOI:10.1037//0735-7044.111.1.104

PMID:9109628

Abstract

This study examined the effect of hippocampal lesions on acquisition of the Morris water maze and conditioned-fear task in inbred mice. C57BL/6J, DBA/2J, and B6D2F1 hybrid mice were given hippocampal lesions or sham surgery and then tested. The lesioned C57BL/6J and B6D2F1 mice failed to learn the Morris task relative to sham-operated controls, and no DBA group learned the task. In the contextual component of conditioned fear, lesions decreased freezing in all strains. But the lesions only affected freezing to the conditioned stimulus in the DBA/2J and B6D2F1 strains. These data demonstrate that C57BL/6J and B6D2F1 mice use the hippocampus to solve the Morris water maze and conditioned-fear task, and the DBA mice use the hippocampus, to some degree, in the conditioned-fear task.

摘要

本研究考察了海马损伤对近交系小鼠在莫里斯水迷宫任务和条件性恐惧任务学习中的影响。对C57BL/6J、DBA/2J和B6D2F1杂交小鼠进行海马损伤或假手术，然后进行测试。与假手术对照组相比，海马损伤的C57BL/6J和B6D2F1小鼠未能学会莫里斯任务，且没有DBA组小鼠学会该任务。在条件性恐惧的情境部分，损伤降低了所有品系小鼠的僵立反应。但损伤仅影响DBA/2J和B6D2F1品系小鼠对条件刺激的僵立反应。这些数据表明，C57BL/6J和B6D2F1小鼠利用海马体来完成莫里斯水迷宫任务和条件性恐惧任务，而DBA小鼠在一定程度上利用海马体来完成条件性恐惧任务。