Waterman A E, Amin A
Department of Veterinary Surgery, University of Bristol, Langford, UK.
Equine Vet J Suppl. 1992 Feb(11):56-8. doi: 10.1111/j.2042-3306.1992.tb04774.x.
The plasma concentration of pethidine was measured in 16 horses, after its administration intravenously (i.v.) at a dose rate of 1 mg/kg bodyweight (bwt). In eight animals studied before surgery, the plasma levels of the drug decreased in a bi-exponential manner with a distributive half life of 3 mins and an elimination half life of 57.7 mins. Total body clearance was 17.7 ml/kg bwt/min. The remaining horses were investigated immediately after a period of anaesthesia and surgery and in these animals the drug exhibited smaller volumes of distribution (V1 cand Vdarea) and a significantly lower clearance rate of 12.8 ml/kg bwt/min in these animals. Correlation between the plasma concentration of pethidine and information published previously on the duration of action of the agent in the horses suggests that plasma levels of approximately 0.4 microgram/ml are required to produce analgesia in this species.
对16匹马静脉注射哌替啶，剂量为1毫克/千克体重，之后测量其血浆浓度。在8只术前研究的动物中，药物血浆水平呈双指数下降，分布半衰期为3分钟，消除半衰期为57.7分钟。总体清除率为17.7毫升/千克体重/分钟。其余马匹在一段麻醉和手术后立即进行研究，在这些动物中，药物表现出较小的分布容积（V1和Vdarea），清除率显著降低，为12.8毫升/千克体重/分钟。哌替啶血浆浓度与先前发表的关于该药物在马体内作用持续时间的信息之间的相关性表明，该物种产生镇痛作用所需的血浆水平约为0.4微克/毫升。
