Rolim J A, Barsottini O G, Prado G F, Nakandakare F, Reis M L, Reis-Filho J B
Escola Paulista de Medicina (EPM) da Universidade Federal de São Paulo(UNIFESP), Brasil.
Arq Neuropsiquiatr. 1996 Sep;54(3):479-83. doi: 10.1590/s0004-282x1996000300019.
We describe the case of a 28-year-old man with a giant congenital melanocytic nevus (GCMN) with malignant transformation to melanoma and metastasis on the central nervous system (CNS). We also make a summary of the pathological features from both lesions (GCMN and Melanoma), the occurrence of malignancy of GCMN, the organs more frequently involved with metastatic melanoma--with emphasis to involvement of CNS--just as the factors that cause malignant transformation of GCMN; the methods to diagnose metastases in CNS--emphasizing the importance of cerebrospinal fluid--and some therapeutical modalities for the metastatic melanoma in CNS.
我们描述了一名28岁男性患者的病例，该患者患有巨大先天性黑素细胞痣（GCMN），已发生恶性转化为黑色素瘤并转移至中枢神经系统（CNS）。我们还总结了两种病变（GCMN和黑色素瘤）的病理特征、GCMN的恶性发生率、转移性黑色素瘤更常累及的器官——重点是CNS受累情况——以及导致GCMN恶性转化的因素；诊断CNS转移的方法——强调脑脊液的重要性——以及CNS转移性黑色素瘤的一些治疗方式。
