Schubert S, Lebeau A, Zell R, Goebel F
Max von Pettenkofer-Institut fuer Hygiene und Mikrobiologie, Pettenkoferstr. 9a, Munich, D-80336, Germany.
Eur J Med Res. 1997 Apr 21;2(4):173-6.
We report on a 39-year-old AIDS patient who presented a generalized cryptococcal disease with involvement of the lungs and central nervous system. Although the initial symptoms were mild and uncharacteristic, the radiological finding of cavernous destructions of the lungs (cryptococcoma) was detectable. The patient recovered after an initial 3 week therapy with amphotericin B and fluconazole followed by secondary prevention with fluconacole. The cavernous destructions receded within 4 months. Though the respiratory tract is the presumed port of entry for Cryptococcus neoformans, a cavernous destruction of pulmonary tissue without a diffuse infiltration of the lungs is a rare manifestation of cryptococcosis even in HIV patients.
我们报告了一名39岁的艾滋病患者，其患有累及肺部和中枢神经系统的播散性隐球菌病。尽管最初症状较轻且不典型，但肺部海绵状破坏（隐球菌瘤）的影像学表现是可检测到的。患者在最初接受3周的两性霉素B和氟康唑治疗，随后用氟康唑进行二级预防后康复。肺部海绵状破坏在4个月内消退。尽管呼吸道被认为是新型隐球菌的进入途径，但即使在艾滋病毒患者中，肺部组织出现海绵状破坏而无肺部弥漫性浸润也是隐球菌病的罕见表现。
