人类前列腺液的质子磁共振波谱分析：枸橼酸盐、精胺和肌醇水平之间的相关性以及疾病导致的变化。
Proton MRS of human prostatic fluid: correlations between citrate, spermine, and myo-inositol levels and changes with disease.
作者信息
Lynch M J, Nicholson J K
机构信息
Institute of Urology and Nephrology, Birkbeck College, University of London, United Kingdom.
出版信息
Prostate. 1997 Mar 1;30(4):248-55. doi: 10.1002/(sici)1097-0045(19970301)30:4<248::aid-pros4>3.0.co;2-h.
BACKGROUND
This is a study of the unusual small molecular components of human prostatic fluid using a non-destructive technique.
METHODS
Single pulse high resolution proton MRS of 38 human prostatic fluid samples (12 control, 10 with benign prostatic enlargement, 4 with prostatic cancer, 11 with vasal aplasia, and one with prostatodynia). Regression models for the metabolites measured were made and compared, and correlations were analyzed.
RESULTS
A very strong correlation between the secretion of citrate and spermine (r = 0.94), two of the major components of prostatic fluid, was found. The molar ratio was 5:1 citrate: spermine. There was no difference seen between samples obtained by expression or ejaculation. The regression models suggest there is a significant difference (P < 0.02) in the citrate to spermine ratio in prostatic fluid from men with prostate cancer, with a relatively higher level of spermine.
CONCLUSIONS
The authors speculate that citrate and spermine secretion is linked and may be forming a novel complex.
背景
本研究采用非破坏性技术对人类前列腺液中异常的小分子成分进行研究。
方法
对38份人类前列腺液样本（12份对照样本、10份良性前列腺增生样本、4份前列腺癌样本、11份输精管发育不全样本以及1份前列腺痛样本）进行单脉冲高分辨率质子磁共振波谱分析。建立并比较所测代谢物的回归模型，并分析相关性。
结果
发现前列腺液的两种主要成分柠檬酸盐和精胺的分泌之间存在非常强的相关性（r = 0.94）。摩尔比为柠檬酸盐：精胺 = 5:1。通过挤压或射精获得的样本之间未发现差异。回归模型表明，前列腺癌患者前列腺液中柠檬酸盐与精胺的比例存在显著差异（P < 0.02），精胺水平相对较高。
结论
作者推测柠檬酸盐和精胺的分泌相互关联，可能正在形成一种新型复合物。
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