Weis Jan, von Below Catrin, Tolf Anna, Ortiz-Nieto Francisco, Wassberg Cecilia, Häggman Michael, Ladjevardi Sam, Ahlström Håkan
Department of Radiology, Uppsala University Hospital, Uppsala, Sweden.
Department of Pathology, Uppsala University Hospital, Uppsala, Sweden.
J Magn Reson Imaging. 2017 Apr;45(4):1232-1240. doi: 10.1002/jmri.25443. Epub 2016 Aug 24.
To estimate concentrations of choline (Cho), spermine (Spm), and citrate (Cit) in prostate tissue using 3D proton magnetic resonance spectroscopic imaging (MRSI) with water as an internal concentration reference as well as to assess the relationships between the measured metabolites and also between the metabolites and apparent diffusion coefficient (ADC).
Forty-six prostate cancer patients were scanned at 3T. Spectra were acquired with the point-resolved spectroscopy (PRESS) localization technique. Single-voxel spectra of four healthy volunteers were used to estimate T relaxation time of Spm. Spm, Cho concentrations, and ADC values of benign prostate tissues were correlated with Cit content.
The T value, 708 ± 132 msec, was estimated for Spm. Mean concentrations in the benign peripheral zone (PZ) were Cho, 4.5 ± 1 mM, Spm, 13.0 ± 4.4 mM, Cit, 64.4 ± 16.1 mM. Corresponding values in the benign central gland (CG) were Cho, 3.6 ± 1 mM, Spm, 13.3 ± 4.5 mM, Cit, 34.3 ± 12.9 mM. Concentrations of Cit and Spm were positively correlated in the benign PZ zone (r = 0.730) and CG (r = 0.664). Positive correlation was found between Cit and Cho in the benign CG (r = 0.705). Whereas Cit and ADC were positively correlated in the benign PZ (r = 0.673), only low correlation was found in CG (r = 0.265).
We have shown that it is possible to perform water-referenced quantitative 3D MRSI of the prostate at the cost of a relatively short prolongation of the acquisition time. The individual metabolite concentrations provide additional information compared to the previously used metabolite-to-citrate ratios.
1 J. Magn. Reson. Imaging 2017;45:1232-1240.
采用以水作为内部浓度参考的三维质子磁共振波谱成像（MRSI）技术估算前列腺组织中胆碱（Cho）、精胺（Spm）和柠檬酸盐（Cit）的浓度，并评估所测代谢物之间以及代谢物与表观扩散系数（ADC）之间的关系。
对46例前列腺癌患者进行3T扫描。采用点分辨波谱（PRESS）定位技术采集波谱。利用4名健康志愿者的单体素质子磁共振波谱估算Spm的T弛豫时间。将良性前列腺组织的Spm、Cho浓度及ADC值与Cit含量进行相关性分析。
估算出Spm的T值为708±132毫秒。良性外周带（PZ）的平均浓度为：Cho 4.5±1 mM，Spm 13.0±4.4 mM，Cit 64.4±16.1 mM。良性中央腺体（CG）的相应值为：Cho 3.6±1 mM，Spm 13.3±4.5 mM，Cit 34.3±12.9 mM。在良性PZ区（r = 0.730）和CG区（r = 0.664），Cit和Spm的浓度呈正相关。在良性CG区，Cit和Cho呈正相关（r = 0.705）。虽然在良性PZ区，Cit和ADC呈正相关（r = 0.673），但在CG区仅发现低度相关（r = 0.265）。
我们已经证明，以相对较短的采集时间延长为代价，可以对前列腺进行以水为参考的定量三维MRSI。与先前使用的代谢物与柠檬酸盐的比值相比，个体代谢物浓度提供了更多信息。
1 J. Magn. Reson. Imaging 2017;45:1232 - 1240。
