Hanifin J M, Rogge J L
Arch Dermatol. 1977 Oct;113(10):1383-6.
Cutaneous staphylococcal infections appear to be relatively infrequent in atopic dermatitis even though patients have broken skin heavily colonized with staphylococcal organsism. We found superficial staphylococcal pustules on the skin of 22 patients with atopic dermatitis. Such lesions were more commonly found with severe exacerbations of atopic dermatitis. They appeared on unbroken skin independent of hair follicles and were associated with considerable pruritus. Such lesions were rapidly removed by excoriation and frequently were overlooked by patients and physicians. Most lesions appeared when polymorphonuclear leukocyte chemotaxis was depressed. Ineffective chemotaxis combined with high-colonization density and inadequate stratum corneum barrier during exacerbations of atopic dermatitis may lead to mild staphylococcal infections. These infections appear to have no systemic effects but possibly the considerable associated pruritus could worsen the atopic dermatitis. Occasional patients may require intermittent or continuous antibiotic therapy.
皮肤葡萄球菌感染在特应性皮炎中似乎相对少见，尽管患者皮肤破损且被葡萄球菌大量定植。我们在22例特应性皮炎患者的皮肤上发现了浅表葡萄球菌脓疱。此类皮损在特应性皮炎严重加重时更常见。它们出现在完整皮肤上，与毛囊无关，且伴有明显瘙痒。此类皮损会因搔抓而迅速消失，患者和医生常对此忽视。大多数皮损出现在多形核白细胞趋化性受抑制时。在特应性皮炎加重期间，趋化性无效、定植密度高以及角质层屏障不足可能导致轻度葡萄球菌感染。这些感染似乎没有全身影响，但可能与之相关的明显瘙痒会使特应性皮炎恶化。偶尔有患者可能需要间歇性或持续性抗生素治疗。
