Weinberg J M, Wolfe J T, Sood S, Saruk M, Rook A H, Spiers E M
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, USA.
Acta Derm Venereol. 1997 Mar;77(2):146-8. doi: 10.2340/00015555577146148.
Interferons are cytokines produced by cells in response to stimulation by certain antigens and infectious agents. In recent years, recombinant interferons have been developed, which have antiviral, antiproliferative, and immunomodulatory functions. Several cutaneous reactions have been reported, including cutaneous ulceration at injection sites. We now report three cases of cutaneous ulceration caused by interferon beta-1b injections. In addition, we review all of the previously reported cases of cutaneous ulceration caused by recombinant interferons and discuss the different mechanisms by which these substances may produce this effect.
干扰素是细胞在受到某些抗原和感染因子刺激后产生的细胞因子。近年来，已开发出重组干扰素，其具有抗病毒、抗增殖和免疫调节功能。已有多种皮肤反应的报道，包括注射部位的皮肤溃疡。我们现报告3例由β-1b干扰素注射引起的皮肤溃疡病例。此外，我们回顾了先前报道的所有重组干扰素引起皮肤溃疡的病例，并讨论了这些物质产生这种效应的不同机制。
