Leroy D, Dompmartin A, Szczurko C
Department of Dermatology of Caen, France.
Photodermatol Photoimmunol Photomed. 1996 Oct;12(5):216-8. doi: 10.1111/j.1600-0781.1996.tb00203.x.
Flutamide is a non-steroid antiandrogen used in advanced prostate cancer. This drug induces liver toxicity. Other side effects have been reported, especially four cases of photosensitivity. Our patient presented a sun-exposed eruption that disappeared when flutamide was discontinued and relapsed when it was rechallenged. Photopatch tests were negative. UVA MED was much lower during the treatment and the rechallenge of flutamide. The action spectrum of the drug seems to be in the UVA range. According to the literature, this photosensitivity is probably due to a photo-allergic mechanism.
氟他胺是一种用于晚期前列腺癌的非甾体类抗雄激素药物。该药物会引发肝毒性。还报告了其他副作用，尤其是4例光敏反应。我们的患者出现了暴露于阳光下的皮疹，停用氟他胺后皮疹消失，再次使用时复发。光斑贴试验为阴性。在使用氟他胺治疗及再次用药期间，最小红斑量（UVA MED）低得多。该药物的作用光谱似乎在UVA范围内。根据文献，这种光敏反应可能是由光过敏机制引起的。
