Robak J, Gryglewski R J
Department of Pharmacology, Medical College of Jagiellonian University, Kraków, Poland.
Pol J Pharmacol. 1996 Nov-Dec;48(6):555-64.
Flavonoids are benzo-gamma-pyrone derivatives of plant origin. They possess wide spectrum of biological activity. From the therapeutical point of view the most important are their antioxidant properties. These are the result of high propensity to electron transfer, ferrous ions chelating activity and direct scavenging of reactive oxygen species. Flavonoids inhibit enormous number of enzymes. From the pharmacological point of view inhibition of cyclooxygenase and lipoxygenases as well as scavenging of superoxide anions seem to be essential. Flavonoids are antiinflammatory agents as the result of diminished formation of proinflammatory mediators (prostaglandins, leukotrienes, reactive oxygen species, nitric oxide). They are also antithrombotic owing to their ability to scavenge superoxide anions. These anions are strong inhibitors of prostacyclin production. Removal of superoxide anions by flavonoids facilitates antiaggregatory PGI2 formation. Superoxide anions generate proagregatory isoprostanes. The antiaggregatory effect of flavonoids may be due to the limitation of formation of isoprostanes. Empirical use of flavonoids as drugs acquired recently scientific confirmation.
黄酮类化合物是植物来源的苯并 -γ- 吡喃酮衍生物。它们具有广泛的生物活性。从治疗角度来看，其最重要的是抗氧化特性。这些特性是由于其具有高电子转移倾向、亚铁离子螯合活性以及对活性氧的直接清除作用。黄酮类化合物能抑制大量酶。从药理学角度来看，抑制环氧化酶和脂氧合酶以及清除超氧阴离子似乎至关重要。黄酮类化合物是抗炎剂，因为促炎介质（前列腺素、白三烯、活性氧、一氧化氮）的形成减少。它们还具有抗血栓形成作用，这归因于其清除超氧阴离子的能力。这些阴离子是前列环素产生的强抑制剂。黄酮类化合物清除超氧阴离子有助于抗聚集性前列环素I2的形成。超氧阴离子会生成促聚集性异前列腺素。黄酮类化合物的抗聚集作用可能是由于异前列腺素形成受限。黄酮类化合物作为药物的经验性应用最近获得了科学证实。
