Agrawal P, Laloraya M M
Biochem J. 1977 Aug 15;166(2):205-8. doi: 10.1042/bj1660205.
The lutropin-induced depletion of ascorbate in corpora lutea of albino-rat ovary is shown to be associated with the induction of peroxidase in corpora lutea. An inverse relationship between ascorbate depletion and peroxidase activity was established in a time-course study with lutropin. Analyses made at different phases of the reproductive cycle are in accord with this relationship. It is suggested that ascorbate, which is a well-established donor in peroxidase reactions, undergoes rapid oxidation in the presence of this enzyme, producing an intermediate free radical which, if coupled with pregnenolone, might produce progesterone in the corpora lutea. The exact role of peroxidase in steroidogenesis, however, remains to be elucidated and established.
促黄体生成素诱导白化大鼠卵巢黄体中抗坏血酸的消耗，被证明与黄体中过氧化物酶的诱导有关。在一项关于促黄体生成素的时间进程研究中，确定了抗坏血酸消耗与过氧化物酶活性之间的反比关系。在生殖周期不同阶段进行的分析与这种关系一致。有人提出，抗坏血酸是过氧化物酶反应中公认的供体，在这种酶的存在下会迅速氧化，产生一种中间自由基，如果与孕烯醇酮结合，可能在黄体中产生孕酮。然而，过氧化物酶在类固醇生成中的确切作用仍有待阐明和确定。
