Robbins S J, Ehrman R N, Childress A R, O'Brien C P
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104-6178, USA.
Addict Behav. 1997 Mar-Apr;22(2):157-67. doi: 10.1016/s0306-4603(96)00007-x.
In response to cocaine cues, 150 subjects with a history of cocaine abuse showed decreases in skin temperature and skin resistance and increases in heart rate and reported craving, high, and withdrawal responses. These responses were consistent across four years of data collection. Craving reports were not consistently associated with either high or withdrawal responses, and many subjects endorsed increases in both high and withdrawal states. Correlations revealed no pattern of association among physiological variables and responding did not differ between subjects who did and those who did not report increases in each of the drug states. Finally, physiological variables did not predict reported drug states in discriminant analyses. Cocaine cue reactivity cannot be easily related to a unitary state of high, withdrawal, or craving. It is suggested that future studies focus more on the prediction and measurement of treatment outcome than on the form of cue responses.
在对可卡因线索的反应中，150名有可卡因滥用史的受试者皮肤温度和皮肤电阻下降，心率增加，并报告有渴望、兴奋和戒断反应。这些反应在四年的数据收集过程中是一致的。渴望报告与兴奋或戒断反应并不总是相关，许多受试者认可兴奋和戒断状态都有所增加。相关性分析显示生理变量之间没有关联模式，报告每种药物状态增加的受试者与未报告的受试者之间的反应没有差异。最后，在判别分析中，生理变量无法预测报告的药物状态。可卡因线索反应性不易与单一的兴奋、戒断或渴望状态相关联。建议未来的研究更多地关注治疗结果的预测和测量，而不是线索反应的形式。
