Bauer L O, Kranzler H R
Department of Psychiatry, University of Connecticut Health Center, Farmington 06030.
Biol Psychiatry. 1994 Aug 1;36(3):189-97. doi: 10.1016/0006-3223(94)91224-6.
Electroencephalographic (EEG) and subjective reactions to cocaine cues were evaluated in 18 cocaine-dependent outpatients, after 14 or fewer days of abstinence, and 16 noncocaine-dependent controls. EEG activity and desire for cocaine were recorded while subjects viewed three 5-min films that featured either cocaine-associated, erotic, or neutral stimuli. Other measures of mood state and cocaine craving, derived from the Mood Adjective Checklist and the Cocaine Craving Questionnaire, respectively, were recorded immediately after each film. Analyses of absolute EEG power within six frequency bands (delta, theta, slow and fast alpha, slow and fast beta) revealed no EEG abnormalities in the cocaine-dependent group under any condition. In both subject groups, the cocaine-associated and erotic films produced a similar reduction in total EEG power. The cocaine-associated and erotic films also produced a similar increase in the self-rated desire for cocaine, but this change only occurred in the cocaine-dependent group.
对18名可卡因依赖门诊患者（禁欲14天或更短时间后）和16名非可卡因依赖对照者的脑电图（EEG）及对可卡因线索的主观反应进行了评估。在受试者观看三部时长5分钟的影片时，记录EEG活动和对可卡因的渴望，这些影片分别以与可卡因相关、色情或中性刺激为特色。分别从情绪形容词检查表和可卡因渴望问卷得出的其他情绪状态和可卡因渴望指标，在每部影片播放后立即记录。对六个频段（δ、θ、慢α和快α、慢β和快β）内的绝对EEG功率分析显示，在任何情况下，可卡因依赖组均未出现EEG异常。在两个受试者组中，与可卡因相关和色情的影片均使总EEG功率出现类似程度的降低。与可卡因相关和色情的影片还使自我评定的对可卡因的渴望出现类似程度的增加，但这种变化仅发生在可卡因依赖组中。
