Steele R W, Estrada B, Begue R E, Mirza A, Travillion D A, Thomas M P
Department of Pediatrics, LSU School of Medicine and Children's Hospital, New Orleans, USA.
Clin Pediatr (Phila). 1997 Apr;36(4):193-9. doi: 10.1177/000992289703600402.
This study examined the palatability of 22 antimicrobial suspensions by using five independent categories for scoring: appearance, smell, texture, taste, and aftertaste. The likely overall influence on patient compliance was also evaluated. Drugs were compared within their respective classes. The only antibiotics judged to be so unpalatable as to potentially jeopardize compliance were dicloxacillin, oxacillin, erythromycin/sulfisoxazole, and cefpodoxime. Among the penicillins, amoxicillin and ampicillin were preferred. Azithromycin was slightly superior to erythromycin and clarithromycin within the macrolide class. Many cephalosporins were ranked quite high, the best being loracarbef, cefadroxyl, cefprozil, and cefixime.
本研究通过使用外观、气味、质地、味道和余味五个独立类别进行评分，检验了22种抗菌悬液的适口性。还评估了其对患者依从性可能产生的总体影响。在各自类别内对药物进行了比较。唯一被判定适口性差到可能影响依从性的抗生素是双氯西林、苯唑西林、红霉素/磺胺异恶唑和头孢泊肟。在青霉素类中，阿莫西林和氨苄西林更受青睐。在大环内酯类中，阿奇霉素略优于红霉素和克拉霉素。许多头孢菌素类药物排名相当靠前，表现最佳的是氯碳头孢、头孢羟氨苄、头孢丙烯和头孢克肟。
