Samulak K M, El-Chaar G M, Rubin L G
St. John's University College of Pharmacy, Jamaica, NY, USA.
Pediatr Infect Dis J. 1996 Jan;15(1):14-17. doi: 10.1097/00006454-199601000-00003.
A belief that brand oral liquid medications taste better than their generic counterparts may influence prescribing habits among pediatricians.
We undertook a prospective, randomized, double blinded, comparative evaluation of the taste of brand and generic erythromycin ethylsuccinate, cephalexin monohydrate, erythromycin ethylsuccinate/sulfisoxazole, penicillin V potassium and trimethoprim-sulfamethoxazole in 42 adult volunteers. Subjects tasted one class of brand and generic antibiotics and rated them according to smell, texture, taste and aftertaste.
At least one generic preparation of cephalexin, erythromycin ethylsuccinate/sulfisoxazole and penicillin V potassium was rated equal in taste to the respective brand name products. However, brand erythromycin estolate and trimethoprim-sulfamethoxazole name brand suspensions rated significantly higher than the other products tested.
Based on our results brand name oral antibiotic formulations do not necessarily taste better than their generic counterparts.
认为品牌口服液体制剂比同类非专利药品味道更好的观念可能会影响儿科医生的处方习惯。
我们对42名成年志愿者进行了一项前瞻性、随机、双盲、比较性评估，比较品牌和非专利琥乙红霉素、头孢氨苄、琥乙红霉素/磺胺异恶唑、青霉素V钾和甲氧苄啶-磺胺甲恶唑的味道。受试者品尝一类品牌和非专利抗生素，并根据气味、质地、味道和余味对它们进行评分。
至少有一种头孢氨苄、琥乙红霉素/磺胺异恶唑和青霉素V钾的非专利制剂在味道上被评为与各自的品牌产品相当。然而，品牌依托红霉素和甲氧苄啶-磺胺甲恶唑品牌混悬液的评分明显高于其他测试产品。
根据我们的结果，品牌口服抗生素制剂的味道不一定比同类非专利药品更好。
