Boffetta P, Saracci R, Andersen A, Bertazzi P A, Chang-Claude J, Ferro G, Fletcher A C, Frentzel-Beyme R, Gardner M J, Olsen J H
Unit of Analytical Epidemiology, International Agency for Research on Cancer, Lyon, France.
Scand J Work Environ Health. 1992 Oct;18(5):279-86. doi: 10.5271/sjweh.1576.
One hundred and eighty-one lung cancer deaths among workers during 301,085 person-years in European man-made mineral fiber production between 1930-1955 and 1982 were analyzed according to Poisson regression models including age, calendar period, country, and exposure variables. Time since first employment was the variable most strongly associated with lung cancer risk in both the rock-slag wool and glass wool subcohorts. Workers in the early technological phase were at higher risk than those in other categories, particularly in rock-slag wool production. No clear trend with duration of employment was suggested. No major changes occurred in the interpretation of the results when workers with less than one year of employment or less than 20 years since first exposure were excluded. The original results, based on analyses for standardized mortality ratios, were confirmed, and workers with a short duration of employment or a short time since first employment did not need to be excluded from the analysis.
对1930年至1955年以及1982年期间欧洲人造矿物纤维生产中301,085人年里181例工人肺癌死亡病例，根据包括年龄、日历时间段、国家和暴露变量的泊松回归模型进行了分析。首次就业后的时间是岩棉和玻璃棉亚队列中与肺癌风险关联最强的变量。处于早期技术阶段的工人比其他类别工人的风险更高，尤其是在岩棉生产中。未发现与就业时长有明显趋势。当排除就业不足一年或首次暴露后不足20年的工人时，结果解释未发生重大变化。基于标准化死亡比分析的原始结果得到了证实，就业时长较短或首次就业后时间较短的工人无需从分析中排除。
