Singer C
Movement Disorders Clinic, Department of Neurology, University of Miami School of Medicine, Miami, Florida 33136, USA.
Neurol Clin. 1997 May;15(2):299-308. doi: 10.1016/s0733-8619(05)70314-5.
Coprolalia has been a recognized symptom of Tourette syndrome from the first description of the syndrome. Copropraxia is seen less frequently and almost always occurs in association with coprolalia. Prevalence of coprolalia varies from 8% in primary pediatric practices to over 60% in tertiary referral centers. Coprolalia tends to peak in severity during adolescence and to wane during adulthood. The pathogenesis may be related to dysfunction of basal ganglionic and limbic mini-circuits. Coprolalia has also been seen in a variety of other neurologic disorders. Treatment is primarily pharmacologic with dopamine-blocking agents.
自该综合征首次被描述以来,秽语症一直是妥瑞氏综合征的一个公认症状。秽亵行为较少见,几乎总是与秽语症同时出现。秽语症的患病率在初级儿科诊所为8%,在三级转诊中心则超过60%。秽语症的严重程度往往在青春期达到峰值,在成年期逐渐减弱。其发病机制可能与基底神经节和边缘系统微回路功能障碍有关。秽语症也见于多种其他神经系统疾病。治疗主要采用多巴胺阻断剂进行药物治疗。