Bonifati C, Carducci M, Mussi A, D'Auria L, Ameglio F
Department of Dermatology, Institute S. Gallicano, Rome, Italy.
Drugs Aging. 1998 Mar;12(3):177-90. doi: 10.2165/00002512-199812030-00002.
Psoriasis is a chronic dermatological disorder that affects 1 to 2% of the general population. Although its aetiology is still unknown, the importance of genetic factors has been confirmed by many studies, mainly in young individuals. With respect to clinical features, plaque-type psoriasis (localised or generalised) is the most common form. At present, there is no cure for psoriasis and the available treatments can only temporarily clear the skin manifestations. The choice of treatment regimen for psoriasis is based on the severity of the disease, the patient's gender, age, treatment history and level of compliance, and the physician's personal experience. All therapies for psoriasis have different and potentially toxic effects. Therefore, a good knowledge of their relative and absolute contraindications, adverse effects and interactions with other drugs is mandatory. The elderly represent a significant proportion of patients with psoriasis because its prevalence increases with age. Physicians, particularly general practitioners, dermatologists and gerontologists, must be aware of the problems that the treatment of psoriasis in the elderly can present. This is especially important because of the increased risk of adverse drug reactions in the elderly.
银屑病是一种慢性皮肤病,影响着1%至2%的普通人群。尽管其病因尚不清楚,但许多研究已证实遗传因素的重要性,主要是在年轻人中。就临床特征而言,斑块型银屑病(局限性或全身性)是最常见的形式。目前,银屑病无法治愈,现有的治疗方法只能暂时清除皮肤表现。银屑病治疗方案的选择基于疾病的严重程度、患者的性别、年龄、治疗史和依从性水平以及医生的个人经验。所有银屑病治疗方法都有不同的且可能有毒的作用。因此,必须充分了解它们的相对和绝对禁忌证、不良反应以及与其他药物的相互作用。老年人在银屑病患者中占相当大的比例,因为其患病率随年龄增长而增加。医生,尤其是全科医生、皮肤科医生和老年病科医生,必须意识到老年银屑病患者治疗中可能出现的问题。这一点尤为重要,因为老年人发生药物不良反应的风险增加。