Juszczak M, Drobnik J, Guzek J W, Schwarzberg H
Department of Pathophysiology, Medical University of Lodz, Poland.
J Physiol Pharmacol. 1996 Dec;47(4):621-7.
The pineal indoleamine, melatonin, and the hypothalamic neuropeptide, vasopressin, facilitate passive avoidance behaviour in rats. The similarity of the effects suggest that interaction might occur between the two substances. Therefore, the effect of intraperitoneally applied vasopressin and/or melatonin on one-trial learning passive avoidance behaviour was studied in pinealectomized rats. Intraperitoneal treatment with 500 ng vasopressin 1 hr before the retention test increased passive avoidance latency of sham-operated rats. In pinealectomized rats, an identical amount of vasopressin was ineffective. In sham-operated rats, melatonin blocked the effect of vasopressin. It is concluded that vasopressin needs a regulated pineal function for developing effects in passive avoidance behaviour.
松果体吲哚胺褪黑素和下丘脑神经肽加压素可促进大鼠的被动回避行为。两者作用的相似性表明这两种物质之间可能存在相互作用。因此，研究了腹腔注射加压素和/或褪黑素对松果体切除大鼠一次性学习被动回避行为的影响。在保留测试前1小时腹腔注射500纳克加压素可增加假手术大鼠的被动回避潜伏期。在松果体切除的大鼠中，相同剂量的加压素无效。在假手术大鼠中，褪黑素可阻断加压素的作用。得出的结论是，加压素在被动回避行为中发挥作用需要有正常调节的松果体功能。
