Marquis P, Amarenco G, Sapède C, Josserand F, McCarthy C, Zerbib M, Richard F, Jacquetin B, Villet R, Leriche B, Casanova J M, Conquy S, Zafiropoulos M
Prog Urol. 1997 Feb;7(1):56-63.
Urgent micturition interferes with the quality of life (QoL) of women suffering from this symptom. In order to evaluate this disturbance of quality of life and the benefits of treatment, a self-administered questionnaire, specific to the disorders of urgent micturition in women, was developed from a pre-existing scale (Measurement of Urinary Handicap, MUH). The following developmental methodology was adopted: Generation of a first instrument from the patient's descriptions collected by a multidisciplinary group of clinicians: formulation of questions, regrouping of questions into dimensions, choice of reference period and modalities of response. Content validation and test of comprehension in 20 patients. Transverse pilot study (98 patients) designed to reduce the number of questions and analyse the internal reliability and clinical validity. Reproducibility study. The final questionnaire comprises 24 items grouped into 5 dimensions: activities (8 items), emotional repercussions (5), self-image (5), sleep (3), well-being (3). The relevance of regrouping of the questions in their dimension and of calculation of a global score was confirmed by a principal component analysis and multifactorial analysis. The internal reliability and reproducibility of the scores were satisfactory, with a Cronbach alpha of > 0.70 and an intraclass correlation coefficient > 0.80, respectively. The clinical validity of the questionnaire was verified: the QoL scores of patients became significantly lower as the symptoms became more severe. A specific, reliable and clinically valid questionnaire, expressed in the form of a global score and a profile, was able to be developed. The profile of patients suffering from urgent micturition reflects the repercussions of the disease on the major and specific domains of their QoL. This questionnaire presents the required properties to be used in clinical trials designed to evaluate the effects of treatments on the patients' QoL, as a complement to classical clinical evaluations.
尿急会影响出现该症状的女性的生活质量（QoL）。为了评估这种生活质量的干扰以及治疗的益处，在现有的量表（排尿障碍测量量表，MUH）基础上，开发了一份针对女性尿急障碍的自填式问卷。采用了以下开发方法：由多学科临床医生团队收集患者描述，生成第一份问卷：问题的制定、问题按维度重新分组、参考期的选择以及回答方式。对20名患者进行内容效度和理解测试。横向预试验（98名患者）旨在减少问题数量并分析内部信度和临床效度。重复性研究。最终问卷包含24个项目，分为5个维度：活动（8项）、情绪影响（5项）、自我形象（5项）、睡眠（3项）、幸福感（3项）。通过主成分分析和多因素分析证实了问题按维度重新分组以及计算总分的相关性。分数的内部信度和重复性令人满意，克朗巴哈系数分别>0.70和组内相关系数>0.80。验证了问卷的临床效度：随着症状加重，患者的生活质量得分显著降低。能够开发出一份以总分和概况形式呈现的特定、可靠且临床有效的问卷。尿急患者的概况反映了该疾病对其生活质量主要特定领域的影响。作为经典临床评估的补充，这份问卷具备在旨在评估治疗对患者生活质量影响的临床试验中使用所需使用所需的特性。
