Murray A B, Milner R A
Department of Pediatrics, BC's Children's Hospital, Vancouver, Canada.
Pediatr Allergy Immunol. 1996 Aug;7(3):147-50. doi: 10.1111/j.1399-3038.1996.tb00122.x.
Previous studies have found that questions are considerably less sensitive for predicting sensitization to dust mites than to pollens or to household pets. We studied 1160 children with respiratory symptoms to find whether the sensitivity for predicting mite allergy could be increased by asking several rather than single questions. Parents accompanying the children were asked standardized validated questions. Of the four individual questions relevant to mites, the one with the highest sensitivity for predicting a positive skin prick test to this allergen was whether the symptoms were worse when the house was being swept, vacuumed or dusted (29.8%). If an affirmative answer to that question, or to any of the other three questions, was taken as predictive of sensitization, the sensitivity increased to 54.2%. However, requiring only a single affirmative answer to this combination of questions decreased the specificity. The sensitivity of the combination of questions was comparable to that of questions for predicting positive tests to tree pollens (56.4%), cats (56.4%), grass pollens (52.5%) and dogs (51.4%). We conclude that asking a combination of questions is an useful for indicating possible sensitization to dust mite as are questions for detecting sensitization to other common inhalant allergens.
先前的研究发现，相较于花粉或家养宠物，问题在预测对尘螨的致敏反应方面的敏感性要低得多。我们对1160名有呼吸道症状的儿童进行了研究，以探究通过询问多个而非单个问题是否能提高预测螨过敏的敏感性。陪伴孩子的家长被问及经过标准化验证的问题。在与螨相关的四个单独问题中，对于预测针对该过敏原的阳性皮肤点刺试验敏感性最高的问题是，当房屋进行清扫、吸尘或掸灰时症状是否会加重（29.8%）。如果对该问题或其他三个问题中的任何一个问题的肯定回答被视为致敏的预测指标，那么敏感性会提高到54.2%。然而，仅要求对这组问题中的一个肯定回答会降低特异性。这组问题的敏感性与预测对树花粉（56.4%）、猫（56.4%）、草花粉（52.5%）和狗（51.4%）的阳性试验的问题的敏感性相当。我们得出结论，询问一组问题对于指示可能对尘螨致敏是有用的，就如同检测对其他常见吸入性过敏原致敏的问题一样。
