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节段性硬膜外镇痛后的胎儿心率模式与子宫活动

Fetal heart rate patterns and uterine activity after segmental epidural analgesia.

作者信息

Jouppila P, Jouppila R, Käär K, Merilä M

出版信息

Br J Obstet Gynaecol. 1977 Jul;84(7):481-6. doi: 10.1111/j.1471-0528.1977.tb12629.x.

Abstract

The effects of low-dose segmental epidural analgesia on fetal heart rate (FHR) patterns, uterine activity, and some clinical features were examined in a series of 105 normal parturients. The aim of the analgesic technique was to relieve pain during the first stage of labour by blocking the sensory nerve fibres at the spinal level of T 10 to T12, with either 0-5 per cent bupivacaine or bupivacaine with adrenaline 1 : 200 000, the dose varying from 10 to 25 mg. Obvious pathological changes (late decelerations, prolonged fetal bradycardia, variable deceleration, or loss of beat to beat variation) in FHR patterns within the first 30 minutes after the beginning of analgesia were noted in 9 per cent of the patients. Addition of adrenaline to the analgesic agent seemed to reduce uterine activity for 60 minutes after the analgesia and this was reflected in a longer interval between the block and delivery. A 25 per cent fall in systolic blood pressure was recorded in 11 per cent of the patients. Nine patients required vacuum extractions. Our results show that the epidural technique employed has distinct advantages over the previous methods, which require larger doses of the analgesic, agent, and is therefore safer for the fetus; the addition of adrenaline to the analgesic agent is contraindicated.

摘要

在105例正常产妇中,研究了低剂量节段性硬膜外镇痛对胎儿心率(FHR)模式、子宫活动及一些临床特征的影响。该镇痛技术的目的是通过在T10至T12脊髓水平阻断感觉神经纤维,使用0.5%布比卡因或含1:200 000肾上腺素的布比卡因,剂量为10至25mg,以减轻第一产程的疼痛。9%的患者在镇痛开始后的前30分钟内,FHR模式出现明显的病理变化(晚期减速、持续性胎儿心动过缓、变异减速或逐搏变异消失)。在镇痛剂中添加肾上腺素似乎会在镇痛后60分钟内降低子宫活动,这反映在阻滞与分娩之间的间隔时间更长。11%的患者收缩压下降了25%。9例患者需要进行真空吸引助产。我们的结果表明,所采用的硬膜外技术比以前需要更大剂量镇痛剂的方法具有明显优势,因此对胎儿更安全;镇痛剂中添加肾上腺素是禁忌的。

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