Raabe N, Belfrage P
Acta Obstet Gynecol Scand. 1976;55(4):305-10. doi: 10.3109/00016347609158502.
The influence of epidural block with bupivacaine (Marcaine-adrenalin) on fetal heart rate, uterine activity, and the frequency and intensity of contractions was studied in twenty-five nulliparae at term. Uterine activity was found to decrease during the first 30 minutes following epidural block. In the time interval 30 to 40 minutes after epidural block uterine activity increased again and attained the same level as during the last 10 minutes before analgesia. The frequency of uterine contractions did not decrease after the block. The lower levels of uterine contractility were due only to a lower amplitude of the contractions. The regularizing effect of epidural analgesia on incoordinate uterine action was noted. The recording of fetal heart rate in the time interval studied revealed no pathological findings. Mode of delivery, mean labour duration and Apgar scores after epidural block were comparable with earlier studies of a larger patient population. This study suggest that epidural analgesia does not induce any important changes in fetal heart rate but temporarily decreases uterine activity.
对25名足月初产妇研究了布比卡因（耐乐品-肾上腺素）硬膜外阻滞对胎儿心率、子宫活动以及宫缩频率和强度的影响。发现硬膜外阻滞后最初30分钟子宫活动降低。在硬膜外阻滞后30至40分钟的时间段内，子宫活动再次增加，并达到镇痛前最后10分钟时的相同水平。宫缩频率在阻滞之后并未降低。子宫收缩力较低仅归因于宫缩幅度较小。注意到硬膜外镇痛对不协调子宫活动有调节作用。在所研究的时间段内记录的胎儿心率未发现病理结果。硬膜外阻滞后的分娩方式、平均产程和阿氏评分与早期对更多患者群体的研究结果相当。本研究表明，硬膜外镇痛不会引起胎儿心率的任何重要变化，但会暂时降低子宫活动。
