α-生育酚对蝰蛇毒磷脂酶A2损伤作用的溶酶体膜稳定作用
Lysosomal membrane stabilization by alpha-tocopherol against the damaging action of Vipera russelli venom phospholipase A2.
作者信息
Mukherjee A K, Ghosal S K, Maity C R
机构信息
Department of Biochemistry, Burdwan Medical College, India.
出版信息
Cell Mol Life Sci. 1997 Feb;53(2):152-5. doi: 10.1007/pl00000586.
Abstract
This investigation shows the membrane stabilizing effect of alpha-tocopherol against the damaging action of viper venom phospholipase A2 (PLA2). Liver lysosomal membranes from rats fed 100 mg and 200 mg alpha-tocopherol acetate per kilogram of diet were more resistant to damage by viper venom PLA2 compared with vitamin E-deficient rats. The membrane stabilizing effect of vitamin E is proposed to be due to the formation of a complex with the phospholipid hydrolysis products of the membrane.
摘要
本研究显示了α-生育酚对蝰蛇毒磷脂酶A2（PLA2）破坏作用的膜稳定效应。与维生素E缺乏的大鼠相比，每千克饲料中摄入100毫克和200毫克醋酸α-生育酚的大鼠肝脏溶酶体膜对蝰蛇毒PLA2的损伤更具抵抗力。维生素E的膜稳定效应被认为是由于与膜磷脂水解产物形成了复合物。
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