Moore A N, Ingold K U
Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario, Canada.
Free Radic Biol Med. 1997;22(5):931-4. doi: 10.1016/s0891-5849(96)00276-6.
The conversion of alpha-tocopheryl quinone into alpha-tocopherol in humans has been demonstrated. A male subject was given an oral dose of 400 mg of alpha-3,5-[(C2H3)2]-tocopheryl quinone with an evening meal. Analysis of plasma 15 h later by lipid extraction and subsequent GC-MS single ion monitoring revealed the presence of alpha-[5,7-(C2H3)2]-tocopherol at a concentration of 0.4 microM, representing 0.8% of the total tocopherol in the plasma sample. This experiment clearly demonstrates that orally administered alpha-tocopheryl quinone is converted in a low overall yield to alpha-tocopherol in humans. The conversion to alpha-tocopherol of that portion of the quinone dose which was actually absorbed into the blood stream may, however, have been fairly efficient.
已证实人体内α-生育醌可转化为α-生育酚。一名男性受试者晚餐时口服400mgα-3,5-[(C2H3)2]-生育醌。15小时后通过脂质提取和随后的气相色谱-质谱单离子监测分析血浆，结果显示存在浓度为0.4μM的α-[5,7-(C2H3)2]-生育酚，占血浆样品中总生育酚的0.8%。该实验清楚地表明，口服的α-生育醌在人体内以较低的总产率转化为α-生育酚。然而，实际吸收进入血流的那部分醌剂量转化为α-生育酚的效率可能相当高。
