人类红细胞特异性转录因子EKLF定位于19号染色体的p13.12 - p13.13区域。
The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13.
作者信息
van Ree J H, Roskrow M A, Becher A M, McNall R, Valentine V A, Jane S M, Cunningham J M
机构信息
Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
出版信息
Genomics. 1997 Feb 1;39(3):393-5. doi: 10.1006/geno.1996.4472.
Erythroid Krüppel-like factor (EKLF) is a trans-acting factor that binds specifically to the beta-globin promoter CACCC box. EKLF is essential for adult erythroid development in mice. We have cloned and sequenced a cDNA encoding the human homologue of this gene, which shares 69% identity with the mEKLF protein. The expression of hEKLF is restricted to fetal liver and adult bone marrow. The genomic locus of hEKLF was mapped to chromosomal band 19p13.12-p13.13, using fluorescence in situ hybridization.
红系Krüppel样因子（EKLF）是一种反式作用因子，它能特异性结合β-珠蛋白启动子的CACCC盒。EKLF对小鼠成年期红系发育至关重要。我们已克隆并测序了编码该基因人类同源物的cDNA，它与小鼠EKLF蛋白有69%的同源性。hEKLF的表达局限于胎儿肝脏和成人骨髓。利用荧光原位杂交技术，将hEKLF的基因组定位到染色体带19p13.12 - p13.13。
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