三根手指的故事：哺乳动物Sp/XKLF转录因子家族
A tale of three fingers: the family of mammalian Sp/XKLF transcription factors.
作者信息
Philipsen S, Suske G
机构信息
Department of Cell Biology, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands and.
出版信息
Nucleic Acids Res. 1999 Aug 1;27(15):2991-3000. doi: 10.1093/nar/27.15.2991.
Abstract
One of the most common regulatory elements is the GC box and the related GT/CACC box, which are widely distributed in promoters, enhancers and locus control regions of housekeeping as well as tissue-specific genes. For long it was generally thought that Sp1 is the major factor acting through these motifs. Recent discoveries have shown that Sp1 is only one of many transcription factors binding and acting through these elements. Sp1 simply represents the first identified and cloned protein of a family of transcription factors characterised by a highly conserved DNA-binding domain consisting of three zinc fingers. Currently this new family of transcription factors has at least 16 different mammalian members. Here, we will summarise and discuss recent advances that have been directed towards understanding the biological role of these proteins.
摘要
最常见的调控元件之一是GC盒及相关的GT/CACC盒，它们广泛分布于管家基因以及组织特异性基因的启动子、增强子和基因座控制区。长期以来，人们普遍认为Sp1是通过这些基序起作用的主要因子。最近的发现表明，Sp1只是众多通过这些元件结合并起作用的转录因子之一。Sp1仅仅代表了一个转录因子家族中第一个被鉴定和克隆的蛋白质，该家族的特征是具有一个由三个锌指组成的高度保守的DNA结合结构域。目前，这个新的转录因子家族至少有16个不同的哺乳动物成员。在此，我们将总结并讨论在理解这些蛋白质的生物学作用方面所取得的最新进展。
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本文引用的文献
1
Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus.含人类CpG岛的肺Kruppel样因子（LKLF）基因的结构及其在19号染色体p13.11 - 13位点的定位。
FEBS Lett. 1999 Apr 1;448(1):149-52. doi: 10.1016/s0014-5793(99)00348-8.
2
FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes.FKLF，一种激活人类胚胎和胎儿类β珠蛋白基因的新型Krüppel样因子。
Mol Cell Biol. 1999 May;19(5):3571-9. doi: 10.1128/MCB.19.5.3571.
3
The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.转录辅因子复合物CRSP是增强子结合蛋白Sp1活性所必需的。
Nature. 1999 Feb 4;397(6718):446-50. doi: 10.1038/17141.
4
A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells.一种编码在肠上皮细胞中表达的Krüppel样因子家族肠道富集成员的基因。
Nucleic Acids Res. 1999 Mar 1;27(5):1263-70. doi: 10.1093/nar/27.5.1263.
5
The transcriptional program in the response of human fibroblasts to serum.人类成纤维细胞对血清反应中的转录程序。
Science. 1999 Jan 1;283(5398):83-7. doi: 10.1126/science.283.5398.83.
6
Sp3 and Sp4 can repress transcription by competing with Sp1 for the core cis-elements on the human ADH5/FDH minimal promoter.Sp3和Sp4可通过与Sp1竞争人类ADH5/FDH最小启动子上的核心顺式元件来抑制转录。
J Biol Chem. 1999 Jan 1;274(1):20-8. doi: 10.1074/jbc.274.1.20.
7
Loss of LKLF function results in embryonic lethality in mice.LKLF功能丧失导致小鼠胚胎致死。
Transgenic Res. 1998 Jul;7(4):229-38. doi: 10.1023/a:1008809809843.
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Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor.BTEB-1和AP-2rep对AP-2α启动子的转录调控，AP-2rep是一种新型的与wt-1/egr相关的锌指阻遏物。
Mol Cell Biol. 1999 Jan;19(1):194-204. doi: 10.1128/MCB.19.1.194.
9
Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury.Kruppel样因子Zf9/核心启动子结合蛋白和Sp1对转化生长因子β1及其受体的转录激活。损伤后自分泌纤维化的潜在机制。
J Biol Chem. 1998 Dec 11;273(50):33750-8. doi: 10.1074/jbc.273.50.33750.
10
A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro.一种与SWI/SNF相关的染色质重塑复合物E-RC1，是EKLF在体外进行组织特异性转录调控所必需的。
Cell. 1998 Oct 2;95(1):93-104. doi: 10.1016/s0092-8674(00)81785-7.
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