Burge P, Hoy G, Regan P, Milne R
Nuffield Orthopaedic Centre, Oxford, England.
J Bone Joint Surg Br. 1997 Mar;79(2):206-10. doi: 10.1302/0301-620x.79b2.6990.
We investigated the association of Dupuytren's contracture with smoking and with alcohol by a case-control study in which 222 patients having an operation for this condition were matched for age, operation date and gender with control patients having other orthopaedic operations. Fifty of the cases were also each matched with four community controls. Data were collected by postal questionnaire. Dupuytren's contracture needing operation was strongly associated with current cigarette smoking (adjusted odds ratio 2.8 (95% confidence interval (CI) 1.5 to 5.2)). The mean lifetime cigarette consumption was 16.7 pack-years for the cases compared with 12.0 pack-years for the controls (p = 0.016). Dupuytren's contracture was also associated with an Alcohol Use Disorders Test score greater than 7 (adjusted odds ratio 1.9 (95% CI 1.02 to 3.57)). Mean weekly alcohol consumption was 7.3 units for cases and 5.4 units for controls (p = 0.016). The excess risk associated with alcohol did not appear to be due to a confounding effect of smoking, or vice versa. Smoking increases the risk of developing Dupuytren's contracture and may contribute to its prevalence in alcoholics, who tend to smoke heavily.
我们通过一项病例对照研究，调查了掌腱膜挛缩症与吸烟及饮酒之间的关联。在该研究中，222名因掌腱膜挛缩症接受手术的患者，在年龄、手术日期和性别方面与接受其他骨科手术的对照患者进行匹配。其中50例病例还分别与4名社区对照者进行匹配。数据通过邮寄问卷收集。需要手术治疗的掌腱膜挛缩症与当前吸烟密切相关（调整后的优势比为2.8（95%置信区间（CI）为1.5至5.2））。病例组的平均终身吸烟量为16.7包年，而对照组为12.0包年（p = 0.016）。掌腱膜挛缩症还与酒精使用障碍测试得分大于7相关（调整后的优势比为1.9（95%CI为1.02至3.57））。病例组平均每周饮酒量为7.3单位，对照组为5.4单位（p = 0.016）。与酒精相关的额外风险似乎并非由吸烟的混杂效应所致，反之亦然。吸烟会增加患掌腱膜挛缩症的风险，并且可能导致其在酗酒者中更为普遍，因为酗酒者往往吸烟量很大。
