Sakamoto M, Shimizu K, Iida S, Akita T, Moriya H, Nawata Y
Second Department of Internal Medicine, School of Medicine, Chiba University, Chuo-ku, Japan.
J Bone Joint Surg Br. 1997 Mar;79(2):213-9. doi: 10.1302/0301-620x.79b2.7179.
We performed a prospective study using MRI to evaluate early necrosis of the femoral head in 48 patients receiving high-dose corticosteroids for the treatment of various autoimmune-related disorders. The mean interval from the initiation of corticosteroid therapy to the first MRI examination was 2 months (0.5 to 6). MRI was repeated, and the mean period of follow-up was 31 months (24 to 69). Abnormalities were found on MRI in 31 hips (32%). The initial changes showed well-demarcated, band-like zones which were seen at a mean of 3.6 months after initiation of treatment with steroids. In 14 of these hips (45%) there was a spontaneous reduction in the size of the lesions about one year after treatment had started, but there was no further change in size with a longer follow-up.
我们进行了一项前瞻性研究，使用磁共振成像（MRI）评估48例接受大剂量皮质类固醇治疗各种自身免疫相关疾病的患者股骨头早期坏死情况。从开始皮质类固醇治疗到首次MRI检查的平均间隔时间为2个月（0.5至6个月）。MRI检查重复进行，平均随访期为31个月（24至69个月）。31个髋关节（32%）的MRI检查发现异常。初始变化表现为界限清晰的带状区域，平均出现在开始使用类固醇治疗后的3.6个月。在这些髋关节中的14个（45%），治疗开始约一年后病变大小自发缩小，但随访时间延长后大小没有进一步变化。
