Hypothyroidism--a possible etiology of open-angle glaucoma.

BACKGROUND

Recent studies have shown an association between hypothyroidism and primary open-angle glaucoma (POAG). When hypothyroidism occurs, accumulation of hyaluronic acid within the trabecular meshwork may cause an increase in outflow resistance and intraocular pressure (IOP). This increase may be reversible with use of systemic treatment.

METHODS

A hypothyroid patient is described whose IOP inversely varied with the use or the discontinuation of systemic hypothyroid medications.

RESULTS

The patient's IOP was controlled when she complied with systemic treatment.

CONCLUSIONS

In some cases, hypothyroidism may contribute to the genesis of open-angle glaucoma. Systemic treatment alone may be adequate to prevent progression of a glaucomatous diseased state. It may be prudent to investigate the presence of undiagnosed hypothyroidism in individuals with poorly controlled POAG, in individuals with normal-tension glaucoma, and in newly diagnosed cases.