Gillow J T, Shah P, O'Neill E C
Birmingham and Midland Eye Centre, UK.
Eye (Lond). 1997;11 ( Pt 1):113-4. doi: 10.1038/eye.1997.22.
The prevalence of hypothyroidism in British patients with primary open angle glaucoma (POAG) was examined. A recently reported study from Montreal had shown a significant increase (p < 0.004) in biochemical hypothyroidism (23.4%) in a population of 64 POAG patients compared with controls (4.7%). Mechanisms for a possible causal association between the two diseases are discussed, including mucopolysaccharide deposition in the trabecular meshwork and vasculopathy altering ocular bloodflow. Reports of improved glaucoma control following treatment of hypothyroidism are discussed. This study examined 100 consecutive patients with POAG in a specialist glaucoma clinic. All patients were questioned regarding symptoms of thyroid dysfunction and previous thyroid disease. All patients not already taking thyroxine underwent an assay of thyroid stimulating hormone. The 4% (95% CI 1.1-9.4%) prevalence of overt hypothyroidism in our study shows no clinically significant increase either over controls in the Montreal study or over our local population. We conclude that in our local population there is no evidence for a clinically important association of hypothyroidism with glaucoma.
对英国原发性开角型青光眼（POAG）患者甲状腺功能减退症的患病率进行了研究。蒙特利尔最近报道的一项研究显示，在64例POAG患者中，生化性甲状腺功能减退症的患病率（23.4%）与对照组（4.7%）相比显著增加（p < 0.004）。讨论了这两种疾病之间可能存在因果关联的机制，包括小梁网中的粘多糖沉积和改变眼血流量的血管病变。还讨论了甲状腺功能减退症治疗后青光眼控制改善的报告。本研究对一家专业青光眼诊所的100例连续POAG患者进行了检查。所有患者均被询问有关甲状腺功能障碍症状和既往甲状腺疾病的情况。所有未服用甲状腺素的患者均接受了促甲状腺激素检测。我们研究中显性甲状腺功能减退症的患病率为4%（95%可信区间1.1 - 9.4%），与蒙特利尔研究中的对照组或我们当地人群相比，均未显示出临床上的显著增加。我们得出结论，在我们当地人群中，没有证据表明甲状腺功能减退症与青光眼存在临床上重要的关联。
