Nosova I M, Zaets T L, Kotkina T I
Biull Eksp Biol Med. 1977 Sep;84(9):294-7.
Experiments were conducted on rats; a study was made of the activity of lactic dehydrogenase (LDH) and its isoenzymes in the zone of affection and in the adjacent areas of the skin at various periods after the burn infliction; on the 1st--8th day there occurred a reduction of the sum total LDH activity in the scab zone and the underlying tissue by 70--80%, and in the margin and the intact skin--by 50%. These changes were accompanied by shifts in the isoenzymatic LDH spectrum in the affected tissue; the activity of fraction 5 displayed a sharp rise on the 1st day and that of fractions 2 and 3--a reduction, on the contrary, by the 8th day there was seen some diminution of fraction 5 activity and an elevation of fractions 2 and 3 activity. The following picture is observed on the 14th--22nd day after the burn; the sum total LDH activity remains low, the isoenzymatic LDH spectrum in the margin and the scab is largely normalized, whereas in the underlying tissue there persist changes in the LDH enzyme ratio (a reduction of fractions 1--3 activity, and a rise of fraction 5 activity).
在大鼠身上进行了实验；研究了烧伤后不同时期损伤区域及皮肤相邻区域乳酸脱氢酶（LDH）及其同工酶的活性；在第1至8天，痂下区域和深层组织中LDH总活性降低了70%至80%，边缘和未损伤皮肤中降低了50%。这些变化伴随着受影响组织中LDH同工酶谱的改变；第1天第5组分活性急剧上升，而第2和第3组分活性降低，相反，到第8天第5组分活性有所下降，第2和第3组分活性升高。在烧伤后第14至22天观察到以下情况；LDH总活性仍然较低，边缘和痂下的LDH同工酶谱基本恢复正常，而深层组织中LDH酶比例仍有变化（第1至3组分活性降低，第5组分活性升高）。
