Uzbekov M G
Biull Eksp Biol Med. 1977 Sep;84(9):299-301.
The extent of interaction between serotonin (ST) with light and heavy synaptosomes from different brain regions of normal and dark-reared rabbits was studied by the author's technique, using gel filtration. The activity of this interaction in the heavy synaptosomes of the visual cortex and the colliculi superiores of the control rabbits was the same and significantly higher than that in the motor cortex. The light synaptosomes of all the investigated regions were similar by the extent of this process activity. In dark-reared rabbits the activity of ST binding by heavy synaptosomes in the visual cortex and the colliculi superiores decreased by 74--81 per cent only. A fall in the ST binding by light synaptosomes in all the regions was the same (approximately 73 per cent as compared to the control). The results obtained are discussed in the light of a possible mediator or modulator role of ST in the visual system structures.
作者采用凝胶过滤技术，研究了血清素（ST）与正常饲养和黑暗饲养的兔子不同脑区的轻重突触体之间的相互作用程度。对照兔视觉皮层和上丘的重突触体中这种相互作用的活性相同，且显著高于运动皮层。所有研究区域的轻突触体在这一过程的活性程度上相似。在黑暗饲养的兔子中，视觉皮层和上丘的重突触体对ST的结合活性仅下降了74% - 81%。所有区域轻突触体对ST的结合下降情况相同（与对照相比约为73%）。根据ST在视觉系统结构中可能的介质或调节作用对所得结果进行了讨论。
