Patients must be assessed for iodine allergy prior to indocyanine green administration. A scrupulous injection technique will ensure a safe diagnostic procedure. 2. Indocyanine green dye is used for choroidal angiography to diagnose age-related macular degeneration. 3. Indocyanine green dye has no discernable after effects for the patient. It is nontoxic and wholly removed by the liver. Indocyanine green does not show up as skin discoloration.