[An autoradiographic and electron microscopic study of fibroblasts under conditions of stimulation of the wound process].

The effect of potassium orotate on the ultrastructure of fibroblasts and synthesis of RNA by these cells in the course of healing of experimental skin wounds were studied. For this purpose, dayly there were performed autoradiographic and electron-microscopy investigations of the wound areas in animals which were dayly given 0.2 ml of a 2% solution of potassium orotate and also of those in control animals. Under the effect of potassium orotate on accelerated differentiation of fibroblasts was noted, which was accompanied by the appearance of cells with well developed granular endoplasmatic network, with intensive inclusion of a labeled precursor of RNA, earlier, as compared with controls, healing of the wounds. Moreover, the stimulator not only contributed to a more intensive synthesis of RNA, but also hastened the transfer of newly synthesized RNA from nucleus to the cytoplasm of fibroblasts in the period of activecollagenosis.