Ritter B, Säfwenberg J, Olsson K S
Hum Genet. 1984;68(1):62-6. doi: 10.1007/BF00293874.
The frequency of HLA-A3 and HLA-B14 antigens was found to be significantly (P = less than 0.0001) higher in a series of 50 unrelated and unselected Swedish patients with idiopathic hemochromatosis (IH) than in controls, being 66% and 32% for A3 and 22% and 2% for B14. The haplotype A3B14 was associated with the highest risk in this material (relative risk 23.4). One family with this haplotype was traced back to the end of the seventeenth century. The pattern of HLA antigens associated with IH in Sweden shows remarkable similarity to those reported from England and Brittany.
在一组50例未选择的无亲缘关系的瑞典特发性血色素沉着症（IH）患者中，发现HLA - A3和HLA - B14抗原的频率显著高于对照组（P < 0.0001），A3抗原频率分别为66%和32%，B14抗原频率分别为22%和2%。在该样本中，单倍型A3B14与最高风险相关（相对风险为23.4）。一个具有这种单倍型的家族可追溯到17世纪末。瑞典与IH相关的HLA抗原模式与英国和布列塔尼报道的模式显著相似。
