神经突素：一种由神经活动和神经营养因子诱导产生的促进神经突形成的基因。
Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis.
作者信息
Naeve G S, Ramakrishnan M, Kramer R, Hevroni D, Citri Y, Theill L E
机构信息
Department of Molecular Biology, Amgen Inc., Thousand Oaks, CA 91320, USA.
出版信息
Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2648-53. doi: 10.1073/pnas.94.6.2648.
Abstract
Neural activity and neurotrophins induce synaptic remodeling in part by altering gene expression. A cDNA encoding a glycosylphoshatidylinositol-anchored protein was identified by screening for hippocampal genes that are induced by neural activity. This molecule, named neuritin, is expressed in postmitotic-differentiating neurons of the developing nervous system and neuronal structures associated with plasticity in the adult. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures. These data implicate neuritin as a downstream effector of activity-induced neurite outgrowth.
摘要
神经活动和神经营养因子部分地通过改变基因表达来诱导突触重塑。通过筛选由神经活动诱导的海马基因，鉴定出一种编码糖基磷脂酰肌醇锚定蛋白的cDNA。这种分子名为神经突素，在发育中的神经系统有丝分裂后分化的神经元以及与成体可塑性相关的神经元结构中表达。神经突素的信息是由神经元活动以及活性调节的神经营养因子脑源性神经营因子（BDNF）和神经营养因子-3（NT-3）诱导产生的。纯化的重组神经突素可促进原代胚胎海马和皮质培养物中的神经突生长和分支形成。这些数据表明神经突素是活性诱导的神经突生长的下游效应分子。
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