Wagner M M, Darke C
Tissue Antigens. 1979 Aug;14(2):165-8. doi: 10.1111/j.1399-0039.1979.tb00834.x.
HLA typing was performed on 267 Welsh coalworkers with pneumoconiosis (96 cases of simple pneumoconiosis, 115 cases of progressive massive fibrosis and 56 cases of Caplan's Syndrome) and 134 coalworkers with no abnormality. The presence or absence of rheumatoid factor was also determined. The results fail to confirm a previously reported increase in HLA-A1 and B18 in coalworkers with no pneumoconiosis. When correction was made for the number of antigens typed (i) HLA-Bw21 was significantly increased from 1.1% in the total group with pneumoconiosis to 8.2% in coalworkers with no abnormality (P corrected less than 0.032); (ii) HLA-Bw45 was increased in Caplan's Syndrome (10.7%) and Caplan's Syndrome patients with rheumatoid factor (16.1%) when compared to a non-occupationally exposed control group (0.8%) (P corrected = 0.019 and 0.0064 respectively). These results were not significant when comparisons were made with the coalworker group with no abnormality. The apparent higher frequency of Bw45 in Welsh coalworkers is discussed.
对267名患有尘肺病的威尔士煤矿工人（96例单纯尘肺病、115例进行性大块纤维化和56例卡普兰综合征）和134名无异常的煤矿工人进行了HLA分型。还测定了类风湿因子的有无。结果未能证实先前报道的无尘肺病煤矿工人中HLA - A1和B18增加。在对分型抗原数量进行校正后：（i）HLA - Bw21从全部尘肺病组的1.1%显著增加到无异常煤矿工人的8.2%（校正P值小于0.032）；（ii）与非职业暴露对照组（0.8%）相比，卡普兰综合征患者（10.7%）和患有类风湿因子的卡普兰综合征患者（16.1%）中HLA - Bw45增加（校正P值分别为0.019和0.0064）。与无异常的煤矿工人群体进行比较时，这些结果不显著。文中讨论了威尔士煤矿工人中Bw45明显较高的频率。
