Hámori J, Takács J, Görcs T J
Department of Anatomy, Semmelweis University Medical School, Budapest, Hungary.
Acta Biol Hung. 1996;47(1-4):181-94.
Immunocytochemical investigation of metabotrop glutamate receptor la in the cerebellar cortex of rat revealed a presence of this receptor in all cortical inhibitory nerve cells (Purkinje, basket, stellate, Lugaro and Golgi). In addition to the previously described localization of this receptor in Purkinje dendritic spines supplied by parallel and climbing fibres and considered to be responsible for cerebellar long-term depression, we have observed metabotropic glutamate receptor la immunopositivity also in the synapses between parallel fibres and dendrites of basket, stellate and Golgi neurons. The postsynaptic receptor was also present occasionally in inhibitory synapses between stellate cell axons and Purkinje cells as well as between Purkinje axon collaterals and Lugaro cell dendrites. The possibility, that mGluR1a receptors in basket, Golgi and stellate cells might directly or indirectly contribute to cerebellar LTD, is discussed.
对大鼠小脑皮质代谢型谷氨酸受体1a进行免疫细胞化学研究发现，该受体存在于所有皮质抑制性神经细胞（浦肯野细胞、篮状细胞、星形细胞、卢加罗细胞和高尔基细胞）中。除了先前描述的该受体在由平行纤维和攀缘纤维提供的浦肯野树突棘中的定位，且该定位被认为与小脑长时程抑制有关外，我们还观察到代谢型谷氨酸受体1a在篮状细胞、星形细胞和高尔基神经元的平行纤维与树突之间的突触中呈免疫阳性。突触后受体偶尔也存在于星形细胞轴突与浦肯野细胞之间以及浦肯野轴突侧支与卢加罗细胞树突之间的抑制性突触中。本文讨论了篮状细胞、高尔基细胞和星形细胞中的代谢型谷氨酸受体1a受体可能直接或间接促成小脑长时程抑制的可能性。
