Wolf E, Birinyi A, Puskár Z
Department of Anatomy, University Medical School, Debrecen, Hungary.
Acta Biol Hung. 1996;47(1-4):427-39.
The main goal of this paper is twofold. First, to classify some of the quantitative morphological descriptors within a common theoretical framework and to illustrate their use in the neurobiological research. The second aim is to describe how the computer modelling of dendritic impulse propagation could be related to those high-fidelity morphological databases of dendritic arborizations that we had obtained by three-dimensional reconstructions. Most of the illustrative examples cited here were chosen from morphological and computer simulation studies published by our institute in the past few years. The selection of different morphological parameters in reliability tests of our newly developed 3DARBOR three-dimensional neuronal tree reconstruction system was also cited as an example. The advantages of the parallelled morphological and computational approach in the study of dendritic arborizations were discussed. A full flow chart that gives an outline of the methods we followed in setting up a morphologically accurate cable model was also presented.
本文的主要目标有两个。其一，在一个通用理论框架内对一些定量形态学描述符进行分类，并说明它们在神经生物学研究中的应用。第二个目标是描述树突冲动传播的计算机建模如何与我们通过三维重建获得的那些高保真树突分支形态数据库相关联。这里引用的大多数示例均选自我们研究所过去几年发表的形态学和计算机模拟研究。还以我们新开发的3DARBOR三维神经元树重建系统可靠性测试中不同形态学参数的选择为例。讨论了在树突分支研究中并行形态学和计算方法的优势。还给出了一个完整的流程图，概述了我们在建立形态精确的电缆模型时所采用的方法。
