胆碱酯酶。其在麻醉实践中的意义。

Cholinesterase. Its significance in anaesthetic practice.

作者信息

Davis L, Britten J J, Morgan M

机构信息

Royal London Hospital, London, UK.

出版信息

Anaesthesia. 1997 Mar;52(3):244-60. doi: 10.1111/j.1365-2044.1997.084-az0080.x.

DOI:10.1111/j.1365-2044.1997.084-az0080.x

PMID:9124666

Abstract

Plasma cholinesterase is an enzyme which has importance to the anaesthetist primarily for its role in the metabolism of suxamethonium, although other anaesthetic related drugs that this enzyme metabolises are also increasingly important. In this article we review current thoughts on the function, profile and chemistry of plasma cholinesterase. Causes of variations in the activity of the enzyme are described and the basis of genetic variations is explained.

摘要

血浆胆碱酯酶是一种对麻醉医生至关重要的酶，主要因其在琥珀胆碱代谢中的作用，不过该酶代谢的其他与麻醉相关的药物也日益重要。在本文中，我们综述了关于血浆胆碱酯酶的功能、特性及化学性质的当前观点。描述了该酶活性变化的原因，并解释了基因变异的基础。