Mohiuddin M A, Pursnani K G, Katzka D A, Gideon R M, Castell J A, Castell D O
Graduate Hospital, Department of Medicine, Philadelphia, Pennsylvania 19146, USA.
Dig Dis Sci. 1997 Apr;42(4):715-9. doi: 10.1023/a:1018839425118.
Omeprazole is inactivated by exposure to gastric acid and is formulated as a gelatin capsule containing enteric-coated granules that release the drug in alkaline medium. In clinical situations where patients are unable to take the capsule orally, the optimum means of administration is uncertain. Eleven normal volunteers were given omeprazole 20 mg every day for one week before breakfast in random order as either a 20-mg capsule with water or free enteric-coated granules with either 8 oz of orange juice, 8 oz of water with 2 Alka-Seltzer antacid tablets (aspirin free), or 1 teaspoon of apple sauce. On day 7 of each regimen, an 8-hr intragastric pH study was performed following omeprazole 20 mg and standard breakfast. The median percentage of time of gastric acid pH > 4 after an omeprazole capsule was 68.5 (25-100); after granules with orange juice 59 (43-100); after granules in Alka-Seltzer solution 63 (31-100), and after granules in apple sauce 65 (30-99), with no significant differences (ANOVA). The time for the gastric pH to reach <4' after having been above was also similar for all four regimens (ANOVA). Omeprazole granules administered orally in a variety of ways achieve gastric acid suppression as effectively as the intact capsule.
奥美拉唑遇胃酸会失活，其剂型为明胶胶囊，内含肠溶包衣颗粒，该颗粒在碱性介质中释放药物。在临床情况下，若患者无法口服胶囊，最佳给药方式尚不确定。11名正常志愿者被随机安排在早餐前每天服用20毫克奥美拉唑，为期一周，服用方式分别为用水送服20毫克胶囊、用8盎司橙汁送服游离的肠溶包衣颗粒、用8盎司水加2片不含阿司匹林的阿耳卡-塞耳策抗酸片送服游离的肠溶包衣颗粒或用1茶匙苹果酱送服游离的肠溶包衣颗粒。在每种给药方案的第7天，在服用20毫克奥美拉唑和标准早餐后进行了8小时的胃内pH值研究。服用奥美拉唑胶囊后胃酸pH值>4的时间中位数为68.5（25 - 100）；用橙汁送服颗粒后为59（43 - 100）；用阿耳卡-塞耳策溶液送服颗粒后为63（31 - 100），用苹果酱送服颗粒后为65（30 - 99），差异无统计学意义（方差分析）。对于所有四种给药方案，胃酸pH值从高于4降至<4的时间也相似（方差分析）。以多种方式口服的奥美拉唑颗粒抑制胃酸的效果与完整胶囊一样有效。
