奥美拉唑对十二指肠溃疡病患者胃排空的影响。
The effect of omeprazole on gastric emptying in patients with duodenal ulcer disease.
作者信息
Horowitz M, Hetzel D J, Buckle P J, Chatterton B E, Shearman D J
出版信息
Br J Clin Pharmacol. 1984 Nov;18(5):791-4. doi: 10.1111/j.1365-2125.1984.tb02544.x.
Abstract
The effect of a single oral dose of omeprazole (90 mg) on gastric emptying was assessed with a dual isotope scintigraphic technique in eight patients with a history of duodenal ulcer disease. Omeprazole had no significant effect on solid or liquid gastric emptying. The bioavailability (AUC0-2 h) of omeprazole in all patients was greater than that required for total suppression of acid secretion. No adverse clinical or laboratory effects were observed.
摘要
采用双同位素闪烁扫描技术，在8例有十二指肠溃疡病史的患者中评估了单次口服90毫克奥美拉唑对胃排空的影响。奥美拉唑对固体或液体胃排空无显著影响。所有患者中奥美拉唑的生物利用度（AUC0 - 2小时）高于完全抑制胃酸分泌所需的水平。未观察到不良临床或实验室效应。
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