Waldinger M D, Hengeveld M W, Zwinderman A H
Department of Psychiatry and Neurosexology, Leyenburg Hospital, The Hague, The Netherlands.
Br J Urol. 1997 Apr;79(4):592-5. doi: 10.1046/j.1464-410x.1997.00102.x.
To compare the influence of a daily dose of 20 or 40 mg of the serotonergic antidepressant drug paroxetine in delaying ejaculation in patients with primary premature ejaculation.
Thirty-four patients with primary premature ejaculation were randomly assigned to receive 20 mg or 40 mg daily of paroxetine for 7 weeks in a double-blind fixed-dose trial after an initial dose of 20 mg/day in the first week. Patients and their female partners were interviewed separately. In the group receiving 20 mg, one of two capsules consisted of placebo and in the group receiving 40 mg, both capsules contained active drug.
The trial was completed by 27 men; both groups showed a statistically significant difference from the baseline values of ejaculation latency (P < 0.001) and a clinically relevant improvement in ejaculation time. The increase in the intravaginal ejaculation latency time was not statistically significant different between the groups. The patient's assessments were confirmed independently by their partners.
The daily use of 20 mg paroxetine may be considered as an adequate treatment for primary premature ejaculation. Increasing the dose may lead to a further increase in ejaculation latency.
比较每日服用20毫克或40毫克血清素能抗抑郁药物帕罗西汀对原发性早泄患者延迟射精的影响。
34例原发性早泄患者在第一周初始剂量为每日20毫克后，被随机分配接受每日20毫克或40毫克帕罗西汀治疗7周，采用双盲固定剂量试验。分别对患者及其女性伴侣进行访谈。在接受20毫克治疗的组中，两粒胶囊中有一粒为安慰剂；在接受40毫克治疗的组中，两粒胶囊均含活性药物。
27名男性完成了试验；两组射精潜伏期的基线值均有统计学显著差异（P < 0.001），射精时间有临床相关改善。两组间阴道内射精潜伏期时间的增加无统计学显著差异。患者的评估得到了其伴侣的独立证实。
每日服用20毫克帕罗西汀可被视为原发性早泄的一种充分治疗方法。增加剂量可能会导致射精潜伏期进一步延长。
