Oyasu R, Battifora H A, Buckingham W B, Hidvegi D
Cancer. 1977 Mar;39(3):1119-28. doi: 10.1002/1097-0142(197703)39:3<1119::aid-cncr2820390317>3.0.co;2-7.
A 57-year-old man underwent a right pneumonectomy for a bronchogenic carcinoma following bronchoscopy and bronchial biopsy. The tumor was a polypoid mass arising from the lower lobe bronchus. Microscopically it was characterized by mononuclear cells mixed with randomly distributed multinucleated giant cells similar to those seen in giant-cell tumor of bone. Also found were portions showing typical squamous cell and spindle cell carcinoma. Based on the light and electron microscopic findings, we suggest that the current case represents a metaplastic squamous carcinoma showing mesenchymal cell differentiation. A hypothesis on the histogenesis of pleomorphic carcinomas was presented. The problems of histological diagnosis generated by such a tumor should be emphasized.
一名57岁男性在支气管镜检查和支气管活检后因支气管源性癌接受了右肺切除术。肿瘤是一个起源于下叶支气管的息肉样肿块。显微镜下，其特征为单核细胞与随机分布的多核巨细胞混合，类似于骨巨细胞瘤中所见的细胞。还发现有部分区域表现为典型的鳞状细胞癌和梭形细胞癌。基于光镜和电镜检查结果，我们认为本例代表了一种显示间充质细胞分化的化生型鳞状细胞癌。提出了关于多形性癌组织发生的假说。应强调这种肿瘤所产生的组织学诊断问题。
