Kira J, Yamasaki K, Kawano Y, Kobayashi T
Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Neurol Sci. 1997 May 29;148(2):199-203. doi: 10.1016/s0022-510x(97)05369-0.
We herein describe 4 adult patients with upper cervical myelitis presenting with paresthesia in the distal parts of all four limbs and who also all had hyperIgEemia. Two of them had full-blown atopic dermatitis at the time of neurologic illness, while the others had a preceding history of atopic dermatitis. All showed high signal intensity lesions at either the C3 or C4 segment, which mainly affected the posterior column on the T2-weighted spinal cord magnetic resonance imaging. All patients had specific IgE antibodies to two mite antigens and their onset of myelitis coincided with the seasonal increase of the mite antigens in Japan. Therefore, it is possible that the atopic conditions with hyperIgEemia in these patients may thus have contributed to the development of myelitis.
我们在此描述4例成年上颈段脊髓炎患者，他们均表现为四肢远端感觉异常，且均有高IgE血症。其中2例在神经系统疾病发作时患有典型的特应性皮炎，而其他患者有特应性皮炎病史。在T2加权脊髓磁共振成像上，所有患者在C3或C4节段均显示高信号强度病变，主要影响后柱。所有患者对两种螨虫抗原有特异性IgE抗体，且他们的脊髓炎发作与日本螨虫抗原的季节性增加相一致。因此，这些患者的高IgE血症特应状态可能促成了脊髓炎的发生。
