Kira J, Kawano Y, Yamasaki K, Tobimatsu S
Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Neurol Neurosurg Psychiatry. 1998 May;64(5):676-9. doi: 10.1136/jnnp.64.5.676.
An occurrence of acute localised myelitis was recently seen in four adult patients with atopic dermatitis who had hyperIgEaemia and mite antigen specific IgE. The total and mite antigen specific IgE was therefore studied in serum samples from 19 consecutive patients with acute localised myelitis of unknown aetiology, 56 patients with clinically definite multiple sclerosis, and 40 healthy controls. The total IgE concentration was significantly higher in acute localised myelitis (median=360 U/ml) than in multiple sclerosis (median=52 U/ml, p<0.0001) and the controls (median=85 U/ml, p=0.0002). The specific IgE to Dermatophagoides pteronyssinus was found more often in patients with acute localised myelitis (95%) than in patients with multiple sclerosis (34%, p<0.0001) and the controls (35%, p<0.0001) and the specific IgE to Dermatophagoides farinae was similar (acute localised myelitis 79%, multiple sclerosis 29% (p<0.0001), controls 30%, (p=0.0003). Atopic dermatitis coexisted more commonly in patients with acute localised myelitis (37%) than in patients with multiple sclerosis (0%, p<0.0001) and the controls (7.5%, p=0.0089). Therefore, acute localised myelitis with hyperIgEaemia, in which atopy to mite antigens seems to exist, may be a distinct subtype of allergic myelitis-that is, atopic myelitis.
最近在4例患有特应性皮炎、高IgE血症和螨抗原特异性IgE的成年患者中发现了急性局限性脊髓炎。因此，对19例病因不明的急性局限性脊髓炎患者、56例临床确诊的多发性硬化症患者和40名健康对照者的血清样本中的总IgE和螨抗原特异性IgE进行了研究。急性局限性脊髓炎患者的总IgE浓度（中位数=360 U/ml）显著高于多发性硬化症患者（中位数=52 U/ml，p<0.0001）和对照组（中位数=85 U/ml，p=0.0002）。急性局限性脊髓炎患者中抗户尘螨特异性IgE的检出率（95%）高于多发性硬化症患者（34%，p<0.0001）和对照组（35%，p<0.0001），抗粉螨特异性IgE的情况类似（急性局限性脊髓炎患者中为79%，多发性硬化症患者中为29%（p<0.0001），对照组中为30%，（p=0.0003）。急性局限性脊髓炎患者中特应性皮炎共存的情况（37%）比多发性硬化症患者（0%，p<0.0001）和对照组（7.5%，p=0.0089）更为常见。因此，伴有高IgE血症且似乎存在对螨抗原过敏的急性局限性脊髓炎可能是过敏性脊髓炎的一种独特亚型，即特应性脊髓炎。
