Von Hertzen L, Alakärppä H, Koskinen R, Liippo K, Surcel H M, Leinonen M, Saikku P
National Public Health Institute, Helsinki, Finland.
Epidemiol Infect. 1997 Apr;118(2):155-64. doi: 10.1017/s095026889600725x.
The prevalence of chronic Chlamydia pneumoniae infection was assessed in 54 patients with established chronic obstructive pulmonary disease (COPD), 41 of these with severe COPD (group I), 13 with mild to moderate COPD (group II), and in 23 patients with community-acquired pneumonia (controls, group III). Specific IgG and IgA antibody levels and circulating immune complexes (ICs) were measured in paired sera, and specific secretory IgA (sIgA) levels in sputum specimens. A polymerase chain reaction (PCR) test was used for the detection of C. pneumoniae in sputum. According to our definite diagnosis criterion, 65% of the COPD patients showed evidence of suspected chronic C. pneumoniae infection and the prevalence was still higher (71%) in patients with severe disease. The occurrence of specific markers of infection was invariably highest in patients with severe COPD, next-highest in patients with mild to moderate COPD and lowest in pneumonia patients. The association between COPD and C. pneumoniae infection persisted after controlling for the potential confounding factors.
对54例确诊为慢性阻塞性肺疾病（COPD）的患者、41例重度COPD患者（I组）、13例轻至中度COPD患者（II组）以及23例社区获得性肺炎患者（对照组，III组）进行了慢性肺炎衣原体感染患病率的评估。检测配对血清中的特异性IgG和IgA抗体水平以及循环免疫复合物（IC），并检测痰液标本中的特异性分泌型IgA（sIgA）水平。采用聚合酶链反应（PCR）检测痰液中的肺炎衣原体。根据我们明确的诊断标准，65%的COPD患者有疑似慢性肺炎衣原体感染的证据，重度疾病患者的患病率更高（71%）。感染特异性标志物的出现率在重度COPD患者中始终最高，在轻至中度COPD患者中次之，在肺炎患者中最低。在控制潜在混杂因素后，COPD与肺炎衣原体感染之间的关联仍然存在。
